NOTE: Products used in these studies were named Prolact+ H²MF^®and Prolact CR^®. The formulation of Prolact+ H²MF^® and Humavant^TM HMF is the same. The formulation of Prolact CR^® and Humavant^TM CR is the same. Prolact+ H²MF^® and Prolact CR^®are the trade names in North America, and Humavant^TM HMF and Humavant^TM CR are the trade names outside North America.

Reduction in Cost of Care

Huston RK, et al. "Decreasing Necrotizing Enterocolitis and Gastrointestinal Bleeding in the Neonatal Intensive Care Unit: The Role of Donor Human Milk and Exclusive Human Milk Diet in Infants Less 1500 g birth weight." ICAN: Adult Child and Adolescent Nutrition. 20 August 2013. 13:127. doi: 10.1186/1471-2431-13-127

Ganapathy V, et al. “Costs of Necrotizing Enterocolitis and Cost-Effectiveness of Exclusively Human Milk-Based Products in Feeding Extremely Premature Infants.” Breastfeeding Medicine. February 2012. 7(1):29-37. doi: 10.1089/bfm.2011.0002.

Assad M, et al. "Decreased cost and improved feeding tolerance in VLBW infants fed an exclusive human milk diet." Journal of Perinatology. 12 November 2015. doi: 10.1038/jp.2015.168.

Reduction of NEC (Necrotizing Enterocolitis)

Huston RK, et al. "Improving Growth for Infants ≤1250 Grams Receiving an Exclusive Human Milk Diet." Nutrients. February 2018. doi: 10.1002/ncp.10054.

Hair A, et al. "Beyond Necrotizing Enterocolitis Prevention: Improving Outcomes with an Exclusive Human Milk–Based Diet." Breastfeeding Medicine. March 2016. 11(2): 70-74. doi:10.1089/bfm.2015.0134.

Assad M, et al. "Decreased cost and improved feeding tolerance in VLBW infants fed an exclusive human milk diet." Journal of Perinatology. 12 November 2015. doi: 10.1038/jp.2015.168.

Hermann K, et al. “An Exclusively Human Milk Diet Reduces Necrotizing Enterocolitis.” Breastfeeding Medicine. May 2014. 9(4): 184–190. doi: 10.1089/bfm.2013.0121

Cristofalo EA, et al. “Randomized Trial of Exclusive Human Milk versus Preterm Formula Diets in Extremely Premature Infants.” The Journal of Pediatrics. December 2013. 163 (6):1592-1595. doi: 10.1016/j.jpeds.2013.07.011

Hair A, et al. "Human milk feeding supports adequate growth in infants < 1250 grams birth weight." BMC Research Notes. 13 November 2013. doi: 10.1186/1756-0500-6-459

Huston RK, et al. "Decreasing Necrotizing Enterocolitis and Gastrointestinal Bleeding in the Neonatal Intensive Care Unit: The Role of Donor Human Milk and Exclusive Human Milk Diet in Infants Less <= to 1500 g birth weight." ICAN: Adult Child and Adolescent Nutrition. 20 August 2013. 13:127. doi: 10.1186/1471-2431-13-127

Sullivan S, et al. “An exclusively human milk-based diet is associated with a lower rate of necrotizing enterocolitis than a diet of human milk and bovine milk-based products.” The Journal of Pediatrics 2010. doi: 10.1016/j.jpeds.2009.10.040.

Growth

Visuthranukul C, Abrams SA, Hawthorne KM, et al. Premature small for gestational age infants fed an exclusive human milk-based diet achieve catch-up growth without metabolic consequences at 2 years of age." Archives of Disease in Childhood - Fetal and Neonatal Edition Published Online First: 13 November 2018. doi: 10.1136/archdischild-2017-314547

Sandhu A, Fast S, Bonnar K, Baier RJ, Narvey M. Human-Based Human Milk Fortifier as Rescue Therapy in Very Low Birth Weight Infants Demonstrating Intolerance to Bovine-Based Human Milk Fortifier. Breastfeed Med. 2017;12(9):570–573. doi:10.1089/bfm.2017.0017

Huston RK, et al. "Improving Growth for Infants ≤1250 Grams Receiving an Exclusive Human Milk Diet." Nutrients. February 2018. doi : 10.1002/ncp.10054.

Hair A, et al. "Beyond Necrotizing Enterocolitis Prevention: Improving Outcomes with an Exclusive Human Milk–Based Diet." Breastfeeding Medicine. March 2016. 11(2): 70-74. doi :10.1089/bfm.2015.0134.

Hair A, et al. "Human milk feeding supports adequate growth in infants < 1250 grams birth weight." BMC Research Notes. 13 November 2013. doi: 10.1186/1756-0500-6-459

Reduction of TPN Use (Total Parental Nutrition)

Hair AB, et al."Beyond Necrotizing Enterocolitis: Other Clinical Advantages of an Exclusive Human Milk Diet." Breastfeeding Medicine.http://doi.org/10.1089/bfm.2017.0192

Cristofalo EA, et al. “Randomized Trial of Exclusive Human Milk versus Preterm Formula Diets in Extremely Premature Infants.” The Journal of Pediatrics. December 2013. 163(6):1592-1595. doi: 10.1016/j.jpeds.2013.07.011

Ghandehari H, et al.“An Exclusive Human Milk-Based Diet in Extremely Premature Infants Reduces the Probability of Remaining on Total Parenteral Nutrition: A reanalysis of the data.” BMC Pediatrics. 2012. 5: 188. doi:10.1186/1756-0500-5-188.

Flexibility of Feeding

Sandhu A, Fast S, Bonnar K, Baier RJ, Narvey M. Human-Based Human Milk Fortifier as Rescue Therapy in Very Low Birth Weight Infants Demonstrating Intolerance to Bovine-Based Human Milk Fortifier. Breastfeed Med. 2017;12(9):570–573. doi:10.1089/bfm.2017.0017

Guidelines for Acute Care of the Neonate (24th Edition). Texas Children/Baylor College. 2016.

Abrams SA, et al. “Greater mortality and morbidity in extremely preterm infants fed a diet containing cow milk protein products.” Breastfeeding Medicine. June 2014. 9(6): 281-0285. doi:10.1089/bfm.2014.0024.

Hair A, et al. "Human milk feeding supports adequate growth in infants < 1250 grams birth weight." BMC Research Notes. 13 November 2013. doi: 10.1186/1756-0500-6-459

Hair A, et al. "Beyond Necrotizing Enterocolitis Prevention: Improving Outcomes with an Exclusive Human Milk–Based Diet." Breastfeeding Medicine. March 2016. 11(2): 70-74. doi:10.1089/bfm.2015.0134.

Tabata M, et al. "Fortifier and Cream Improve Fat Delivery in Continuous Enteral Infant Feeding of Breast Milk." Nutrients. 11 February 2015. 7(2): 1174-1183. doi:10.3390/nu7021174.

Late Onset of Sepsis

Retinopathy of Prematurity (ROP)

Feeding Intolerance

Sandhu A, Fast S, Bonnar K, Baier RJ, Narvey M. Human-Based Human Milk Fortifier as Rescue Therapy in Very Low Birth Weight Infants Demonstrating Intolerance to Bovine-Based Human Milk Fortifier. Breastfeed Med. 2017;12(9):570–573. doi:10.1089/bfm.2017.0017

Assad M, et al. "Decreased cost and improved feeding tolerance in VLBW infants fed an exclusive human milk diet." Journal of Perinatology. 12 November 2015. doi: 10.1038/jp.2015.168.

Mortality

Assad M, et al. "Decreased cost and improved feeding tolerance in VLBW infants fed an exclusive human milk diet." Journal of Perinatology. 12 November 2015. doi: 10.1038/jp.2015.168.

Ventilation Days

Decreased Length of Stay in the NICU

Hair A, et al. "Premature Infants 750–1,250 g Birth Weight Supplemented with a Novel Human Milk-Derived Cream Are Discharged Sooner Breastfeeding Medicine. April 2016. doi:10.1089/bfm.2015.0166.

Clinical Studies on Humavant CR

Tabata M, et al. "Fortifier and Cream Improve Fat Delivery in Continuous Enteral Infant Feeding of Breast Milk Nutrients February 2015. doi:10.3390/nu7021174.

Hair A, et al. "Randomized Trial of Human Milk Cream as a Supplement to Standard Fortification of an Exclusive Human Milk-Based Diet in Infants 750-1250 g Birth Weight J. Peds November 2014.